We have created a suite of proprietary tools to support decision making in early clinical translation of biomedical science. Each tool is composed of several questions which aim to assess: Reproducibility, Model, Marker & Tissue Validity and Outcome Validity
The tools aim to highlight areas of negative pubication to help the client identify and avoid research spin, stealth research or the lack of evidence for reproducibilty.
We use a traffic light system to grade the validity of the evidence. We highlight areas of concern, where the evidence is robust and indicate where there are evidence gaps
We help our clients identify the best validated models and biomarkers for pre-clinical testing
clarity of methodological reporting
reporting of inter and intra assay variance
reporting of sample size and sample size calculations
use of multiple models/ teams to demonstrate a given result
clarity of methodological reporting
evidence that the model recapitulates the disease of interest (including grade or stage or heterogeneity)
evidence that the marker correctly identifies the target
evidence that the tissue sample(s) recapitulates the disease of interest (including grade or stage or heterogeneity)
clarity of methodological reporting
clarity of definition
consideration of controls and thresholds
consideration of surrogate outcomes and understanding effect
