Systematic review is the methodology underpinning all evidence based decision making. It avoids bias and opinion. Using this technique, we provide a transparent summary of the whole evidence base. We identify the best evidence and the evidence gaps; enabling the client to make informed decisions
We specialise in systematic reviews of early stage preclinical studies: translational medicine, precision medicine, genomics, stem cell therapy, immunotherapy and gene therapy
We bring scientific experience and critical systematic review processes to the preparation of landscape and repurposing reviews - highlighting the strengths, weaknesses and evidence gaps in any unexplored field of interest
We can assess preclinical risk of bias (SYRCLE), biomarker validity, model validity, tissue sample validity, outcome validity
We can evaluate the likelihood of reproducibility in preclinical and biomedical studies
We can help you perform sample size calculations to improve reproducibility and ensure biological/ clinical effect
We can perform meta-analysis and indirect comparisons
Scoping reviews or mapping reviews provide a map of the existing evidence. These aid the planning of research by identifying emerging research and gaps. They are useful for repurposing and identifying a the current knowledge base and for repurposing.