Systematic Review publications

Collins AT, Lang SH. 2018. A systematic review of the validity of patient derived xenograft (PDX) models: the implications for translational research and personalised medicine. PeerJ 6:e5981 https://doi.org/10.7717/peerj.5981

Collins A, Ross J, Lang SH. A systematic review of the asymmetric inheritance of cellular organelles in eukaryotes: A critique of basic science validity and imprecision. Prigent C, editor. PLOS ONE. 2017 May 31;12(5):e0178645. Available from: http://dx.plos.org/10.1371/journal.pone.0178645


Cancer Models

Navone NM, et al., 2018. Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient-derived xenograft (PDX) models. The Prostate, 78(16), pp.1262–1282. Available at: https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.23701.

Taurozzi AJ, et al., 2017. Spontaneous development of Epstein-Barr Virus associated human lymphomas in a prostate cancer xenograft program. PloS one, 12(11), p.e0188228. Available at: http://dx.doi.org/10.1371/journal.pone.0188228.

Frame FM, et al., 2016. Harvesting Human Prostate Tissue Material and Culturing Primary Prostate Epithelial Cells. Methods in molecular biology , 1443, pp.181–201. Available at: http://dx.doi.org/10.1007/978-1-4939-3724-0_12.


Pellacani D, et al., 2018. Phenotype-independent DNA methylation changes in prostate cancer. British journal of cancer, p.33. Available at: http://eprints.whiterose.ac.uk/133612/ [Accessed August 9, 2018].


Butler DE, et al., 2017. Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer. Oncotarget, 8(34), pp.56698–56713. Available at: http://dx.doi.org/10.18632/oncotarget.18082.

Nappo G, et al., 2017. The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling. Oncogenesis, 6(5), p.e342. Available at: http://dx.doi.org/10.1038/oncsis.2017.23.



Rane JK, Erb, H.H.H., et al., 2016. Inhibition of the glucocorticoid receptor results in an enhanced miR-99a/100-mediated radiation response in stem-like cells from human prostate cancers. Oncotarget, 7(32), pp.51965–51980. Available at: http://dx.doi.org/10.18632/oncotarget.10207.

Rane JK, Greener S, et al., 2016. Telomerase Activity and Telomere Length in Human Benign Prostatic Hyperplasia Stem-like Cells and Their Progeny Implies the Existence of Distinct Basal and Luminal Cell Lineages. European urology, 69(4), pp.551–554. Available at: http://dx.doi.org/10.1016/j.eururo.2015.09.039.



Rane JK, Ylipää A, et al., 2015. Construction of therapeutically relevant human prostate epithelial fate map by utilising miRNA and mRNA microarray expression data. British journal of cancer, 113(4), pp.611–615. Available at: http://dx.doi.org/10.1038/bjc.2015.262.

Rane JK, Scaravilli M, et al., 2015. MicroRNA expression profile of primary prostate cancer stem cells as a source of biomarkers and therapeutic targets. European urology, 67(1), pp.7–10. Available at: http://dx.doi.org/10.1016/j.eururo.2014.09.005.

Wanger TM, et al., 2015. Differential regulation of TROP2 release by PKC isoforms through vesicles and ADAM17. Cellular signalling, 27(7), pp.1325–1335. Available at: http://dx.doi.org/10.1016/j.cellsig.2015.03.017.

Zoni E et al., 2015. miR-25 Modulates Invasiveness and Dissemination of Human Prostate Cancer Cells via Regulation of αv- and α6-Integrin Expression. Cancer research, 75(11), pp.2326–2336. Available at: http://dx.doi.org/10.1158/0008-5472.CAN-14-2155.



Pellacani D, et al., 2014. DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation. Cell death and differentiation, 21(5), pp.761–773. Available at: http://www.nature.com/cdd/journal/v21/n5/abs/cdd2013202a.html.

Rane JK, et al., 2014. Conserved two-step regulatory mechanism of human epithelial differentiation. Stem cell reports, 2(2), pp.180–188. Available at: http://dx.doi.org/10.1016/j.stemcr.2014.01.001.

Important papers pre-2014

Kroon P. et al., 2013. JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells. Cancer research, 73(16), pp.5288–5298. Available at: http://dx.doi.org/10.1158/0008-5472.CAN-13-0874.

Lawrence MG. et al., 2013. A preclinical xenograft model of prostate cancer using human tumors. Nature protocols, 8(5), pp.836–848. Available at: http://dx.doi.org/10.1038/nprot.2013.043.

Lang SH, Anderson E, Fordham R, Collins AT. Modeling the Prostate Stem Cell Niche: An Evaluation of Stem Cell Survival and Expansion In Vitro. Stem Cells and Development. 2010 Apr;19(4):537–46. Available from: https://www.liebertpub.com/doi/10.1089/scd.2009.0291

Lang S, Frame F, Collins A. Prostate cancer stem cells. The Journal of Pathology. 2009 Jan;217(2):299–306. Available from: http://doi.wiley.com/10.1002/path.2478

Birnie R, Bryce SD, Roome C, Dussupt V, Droop A, Lang SH, et al. Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions. Genome Biology. 2008;9(5):R83. Available from: http://genomebiology.biomedcentral.com/articles/10.1186/gb-2008-9-5-r83

Collins AT, et al., 2005. Prospective identification of tumorigenic prostate cancer stem cells. Cancer research, 65(23), pp.10946–10951. Available at: http://dx.doi.org/10.1158/0008-5472.CAN-05-2018.

Richardson GD, Robson CN, Lang SH, Neal DE, Maitland NJ, Collins AT. CD133, a novel marker for human prostatic epithelial stem cells. Journal of Cell Science. 2004 Jul 15;117(16):3539–45. Available from: http://jcs.biologists.org/cgi/doi/10.1242/jcs.01222

Collins AT. et al., 2001. Identification and isolation of human prostate epithelial stem cells based on α2β1-integrin expression. Journal of cell science, 114(21), pp.3865–3872. Available at: http://jcs.biologists.org/content/114/21/3865.short [Accessed February 8, 2019].

Robinson EJ, Neal DE & Collins AT, 1998. Basal cells are progenitors of luminal cells in primary cultures of differentiating human prostatic epithelium. The Prostate, 37(3), pp.149–160. Available at: https://www.ncbi.nlm.nih.gov/pubmed/9792132.